Published in a peer-reviewed journalOriginal research

Longitudinal Changes in Regional Brain Volumes and Cognition of Professional Fighters With Traumatic Encephalopathy Syndrome

Brooke D Conway Kleven, Lung-Chang Chien, Brian Labus, Chad L Cross, Aaron Ritter, Rebekah Randall, Arturo Montes, Charles Bernick. 2023. Neurology.

Read the full textDOI 10.1212/wnl.0000000000207594PubMed 37380429

The medical question

How should research measure and protect a fighter’s neurological health over time?

This evidence informs questions about cumulative exposure, neurological assessment and long-term health. The Fight Medicine Research Institute examines the study design, the fighters included and the outcomes measured when developing its own research questions.

Summary

A secondary cohort analysis examined changes in MRI brain volumes and cognitive performance in professional fighters classified using traumatic encephalopathy syndrome criteria.

What the abstract reports

  • Of 130 active and retired professional fighters older than 34, 52 (40%) were classified as meeting the 2021 traumatic encephalopathy syndrome criteria.
  • Over time, the group meeting the criteria showed greater enlargement of the ventricles and greater loss of volume in the hippocampus, subcortical gray matter, total gray matter and posterior corpus callosum than the group that did not.
  • Reaction time and other cognitive scores declined faster in the group meeting the criteria.

Publication status and notices

Published in a peer-reviewed journal. Longitudinal secondary cohort analysis in Neurology. PubMed publication type: Journal Article.

PubMed links a published comment on this article: Neurology. 2023 Sep 12;101(11):461-462. Linked item.

No correction, retraction or expression of concern was found in PubMed, Crossref or Scite when this record was checked.

Fight Medicine Research Institute contribution

Fight Medicine Research Institute selected and catalogued this study, prepared an original research summary, verified its bibliographic details, and maintains the associated citation record.

Article details

Relationship
External research catalogued by the Fight Medicine Research Institute. The original authors, journal and DOI are unchanged.
Published online
No online date in the publisher’s Crossref deposit
Issue date
12 September 2023, volume 101, issue 11
Repository date
28 June 2023 (Europe PMC first-publication date)
Date used here
28 June 2023 (Europe PMC first-publication date)
Rights
No open licence stated. The repository record states no open licence. Treat the article as protected by the publisher’s copyright. Fight Medicine Research Institute links to the source and publishes only its own summary. Publisher’s record.
Source check
, against PubMed (NCBI), Crossref, Europe PMC and Scite. Checked under the direction of Casey C. Sears, Founder. An LLM was utilized as a research tool with direct human oversight.
Appraisal
The check covered bibliographic details, links, licence and notices. It is not a formal critical appraisal of the full paper.
Clinical review
None. This record is a research summary, not clinical education.
Funding and conflicts
See the source record for the authors’ funding and disclosures.
Catalog
FH-006, added

Cite the original work

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