Published in a peer-reviewed journalOriginal research

Longitudinal change in regional brain volumes with exposure to repetitive head impacts

Charles Bernick, Guogen Shan, Henrik Zetterberg, Sarah Banks, Virendra R Mishra, Lynn Bekris, James B Leverenz, Kaj Blennow. 2020. Neurology.

Read the full textDOI 10.1212/wnl.0000000000008817PubMed 31871218

The medical question

How should research measure and protect a fighter’s neurological health over time?

This evidence informs questions about cumulative exposure, neurological assessment and long-term health. The Fight Medicine Research Institute examines the study design, the fighters included and the outcomes measured when developing its own research questions.

Summary

Annual MRI, cognitive testing and blood biomarkers were used to examine changes in regional brain volumes among active and retired fighters and controls.

What the abstract reports

  • 204 participants with at least two assessments were analysed.
  • Compared with controls, active boxers showed a faster yearly decline in the volume of the left thalamus and parts of the corpus callosum. Retired boxers showed the largest declines in the amygdala and right hippocampus.
  • Higher baseline neurofilament light levels were associated with greater volume decline in the left hippocampus and mid anterior corpus callosum.

Publication status and notices

Published in a peer-reviewed journal. Longitudinal cohort analysis in Neurology. PubMed publication type: Journal Article; Observational Study.

PubMed links a published comment on this article: Neurology. 2020 Jan 21;94(3):101-102. Linked item.

No correction, retraction or expression of concern was found in PubMed, Crossref or Scite when this record was checked.

Fight Medicine Research Institute contribution

Fight Medicine Research Institute selected and catalogued this study, prepared an original research summary, verified its bibliographic details, and maintains the associated citation record.

Article details

Relationship
External research catalogued by the Fight Medicine Research Institute. The original authors, journal and DOI are unchanged.
Published online
No online date in the publisher’s Crossref deposit
Issue date
21 January 2020, volume 94, issue 3
Repository date
23 December 2019 (Europe PMC first-publication date)
Date used here
23 December 2019 (Europe PMC first-publication date)
Rights
CC BY-NC-ND 4.0. Open access under a Creative Commons Attribution-NonCommercial-NoDerivatives licence (CC BY-NC-ND 4.0), as recorded by Europe PMC and the licence link in the source record. The licence does not cover commercial reuse or adapted versions. The summary on this page is Fight Medicine Research Institute’s own wording. No abstract text, figure or table from the article is reproduced here. Licence terms.
Source check
, against PubMed (NCBI), Crossref, Europe PMC and Scite. Checked under the direction of Casey C. Sears, Founder. An LLM was utilized as a research tool with direct human oversight.
Appraisal
The check covered bibliographic details, links, licence and notices. It is not a formal critical appraisal of the full paper.
Clinical review
None. This record is a research summary, not clinical education.
Funding and conflicts
See the source record for the authors’ funding and disclosures.
Catalog
FH-003, added

Cite the original work

These files cite the work by its own authors, journal and DOI. Fight Medicine Research Institute appears only in a note, as curator of this catalog page.

Download RISDownload BibTeX

Related on this website